Pyrimidines And Derivatives
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Filtered Search Results
Chemscene ChemScene | 2-Chloro-4-phenylquinazoline | 25G | CS-W019034 | 0.98 | 29874-83-7| MFCD01152724 | 240.69
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ChemScene | 2-Chloro-4-phenylquinazoline | 25G | CS-W019034 | 0.98 | 29874-83-7| MFCD01152724 | 240.69
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370733 MORINIDAZOLE 250MG
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Apexbio Technology LLC BAY 61-3606 732983-37-8 100mg
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BAY 61-3606 (CAS 732983-37-8) is a selective orally bioavailable inhibitor of spleen tyrosine kinase (SYK) displaying an IC50 of 10 nM and a Ki of 7 5 nM for SYK by competitively binding ATP This compound shows minimal activity against other tyrosine kinases such as Src Fyn Lyn Btk and Itk at concentrations up to 4 7 M BAY 61-3606 suppresses Fc RI-mediated degranulation and mediator release in mast cells and basophils as well as Fc R-driven responses in macrophages and neutrophils In preclinical models BAY 61-3606 attenuates inflammatory cell functions and reduces allergic and asthmatic responses supporting its utility in investigating SYK-mediated signaling and inflammation
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Medchemexpress LLC 5,6-Dihydro-5-methyluracil (Dihydrothymine) | 696-04-8 | MFCD00023159 | 100 MG
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5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine, which is found in animals or plants. It is identified as a Human Endogenous Metabolite and an Endogenous metabolite of Human Gut Microbiota.
- Intermediate breakdown product of thymine
- Found in animals or plants
- Human endogenous metabolite
- Endogenous metabolite of human gut microbiota
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Apexbio Technology LLC AXL1717 477-47-4 250mg
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AXL1717 (CAS 477-47-4) also known as picropodophyllin is a selective inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase exhibiting an IC50 of 0 24 0 33 M IGF-1R a transmembrane receptor activated by IGF-1 is implicated in cellular proliferation and survival and its overexpression is associated with various malignancies AXL1717 demonstrates dose-dependent inhibition of cell viability induces G2-M cell cycle arrest and promotes apoptosis in multiple myeloma and colon cancer cell lines In murine xenograft models combination with HDAC inhibitor LBH589 prolongs survival AXL1717 has progressed to phase I/II trials in non-small cell lung cancer
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Medchemexpress LLC 4-pyrimidinecarboxylic acid, methyl ester | 2450-08-0 | MFCD00234184 | 99.0% | 138.12 | C6H6N2O2 | 500 MG
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Methyl pyrimidine-4-carboxylate (4-pyrimidinecarboxylic acid, methyl ester) is a synthetic intermediate used in pharmaceutical and organic synthesis. It is supplied as a high-purity powder for research use.
- High HPLC purity: 98.96% (batch COA).
- Molecular formula C6H6N2O2, molecular weight 138.12 g/mol.
- Typical amount: 500 mg per package.
- Storage stability: powder - 3 years at -20°C, 2 years at 4°C; in solvent - 6 months at -80°C, 1 month at -20°C.
- Intended for research use as a synthetic building block in medicinal chemistry and organic synthesis.
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Cayman Chemical aLinolenic Acid ethyl ester
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An esterified form of α-linolenic acid; increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells at 50 μM; inhibits the growth of S. mutans, C. albicans, and P. gingivalis at 25 μg/ml; has been found in biodiesel produced from castor oil using ethanol; has been used as a substrate in lipid peroxidation assays for antioxidant activity
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Cayman Chemical Arachidonic Acid ethyl ester
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An esterified form of arachidonic acid; commonly used as a source of exogenous arachidonic acid in vivo; has been found in the meconium of newborns suspected of fetal alcohol exposure
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Medchemexpress LLC 2-AMINO-4- 4-PYRIDYL 5G
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5000210752 2-AMINO-4- 4-PYRIDYL 5G
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eMolecules 7-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE | 29064-76-4 | MFCD11846192 | 1g
AstaTech | 7-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE | 1g | 112536160 | SC1171 | 95.000 | 29064-76-4 | MFCD11846192 | 248.520 | C7H3BrClNS
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Medchemexpress LLC Ethyl ferulate | 4046-02-0 | 99.9% | 222.24 | 1 ML
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Ethyl ferulate is a naturally lipophilic derivative of ferulic acid, originally derived from Rhizoma Chuanxiong. It induces heme oxygenase-1 (HO-1) and offers neuroprotection against oxidative stress and amyloid β peptide (1-42)-induced neurotoxicity.
- Induces heme oxygenase-1 (HO-1) expression.
- Protects neurons from oxidative stress.
- Reduces amyloid β peptide (1-42)-induced neurotoxicity.
- Increases HO activity in astrocytes and hippocampal neurons.
- Inhibits LPS-induced acute lung injury.
- Inhibits retinal neovascularization.
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Medchemexpress LLC Methyl heptadecanoate-d33 | 1219804-81-5 | 317.68 | 25 MG
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Methyl heptadecanoate-d33 is a deuterium-labeled form of methyl heptadecanoate, an ester derivative of heptadecanoic acid. It serves as an internal standard for the quantitative calibration of fatty acids in GC-MS analysis. Deuterium labeling is also notable for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Functions as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, or LC-MS applications
- Deuterium labeling can impact pharmacokinetic and metabolic profiles of drugs
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eMolecules EMOLECULES INC
5000224816 TRIS 3 5-BISTRIFLUOROMETHY 1G
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Apexbio Technology LLC Amrinone 60719-84-8 250mg
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Amrinone (CAS 60719-84-8) is a small molecule inhibitor of type 3 phosphodiesterase (PDE3) enzymes By blocking PDE3 activity amrinone increases intracellular cyclic adenosine monophosphate (cAMP) levels leading to enhanced cardiac contractility and vasodilation This mechanism has made amrinone a valuable tool for investigating cardiac function and vascular smooth muscle regulation in preclinical models It is frequently utilized in research focused on the pathophysiology and treatment of congestive heart failure as well as studies exploring intracellular signaling pathways involving cAMP
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Accela Chembio Inc 6-chloro-4 | 5-pyrimidinediamine | 5g | 4316-98-7 | MFCD00023270 | 97+% | Shelf Life: 1260 Days | Light Sensitive/nitrogen Or Argon/+4
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6-chloro-4 | 5-pyrimidinediamine | 5g | 4316-98-7 | MFCD00023270 | 97+% | Shelf Life: 1260 Days | Light Sensitive/nitrogen Or Argon/+4
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